Starga

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Archived from the original on July 24, Retrieved June 28, In some cases, signs of Stargardt's disease appear in early childhood; but a person with Stargardt's particularly the fundus flavimaculatus version of the disease may reach middle age before vision problems are noticed.

Those who have the fundus flavimaculatus form of the disease, however, are likely to experience even more severe vision loss.

Symptoms of Stargardt's disease can include blurry or distorted vision, inability to see in low lighting and difficulty recognizing familiar faces.

In late stages of Stargardt's, color vision also may be lost. Some research indicates that exposure to bright light may play a role in triggering the retinal damage that occurs with Stargardt's.

While there is no known treatment for Stargardt's disease at this time, people with the condition often are advised to wear eyeglasses or sunglasses that block percent of UV light to reduce the possibility of additional eye damage caused by the sun.

If you have Stargardt's, your eye doctor also may suggest that you wear eyeglasses with specially tinted lenses to block certain wavelengths of light.

One company developing a treatment for Stargardt's disease is Astellas formerly Ocata Therapeutics. This stem cell treatment is designed to protect and regenerate photoreceptors in the retina that are damaged by eye diseases like Stargardt's.

Results from Phase I and Phase II clinical trials were encouraging, with significant vision improvements reported for some patients.

Other research suggests aggregation or "clumping" of vitamin A in the retina may be associated both with Stargardt's disease and age-related macular degeneration AMD.

These clumpy deposits are known as "vitamin A dimers. You can use, copy, tranform and build upon the material for non-commercial purposes as long as you give appropriate credit by citing our paper, and indicate if changes were made.

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Top bonuses! Enjoy loads of bonuses and promotions. As a VIP you can enjoy a host of benefits. Lipofuscin deposits can be seen as yellowish flecks in the macula.

The flecks are irregular in shape and usually extend outward from the macula in a ring-like pattern. Currently, there is no treatment for Stargardt disease.

Some ophthalmologists encourage people with Stargardt disease to wear dark glasses and hats when out in bright light to reduce the buildup of lipofuscin.

Cigarette smoking and second hand smoke should be avoided. Animal studies suggest that high-dose vitamin A may increase lipofuscin accumulation and potentially accelerate vision loss.

A number of services and devices can help people with Stargardt disease carry out daily activities and maintain their independence.

Because many people with Stargardt disease will become visually disabled by their 20s, the disease can have a significant emotional impact. Work, socializing, driving and other activities that may have come easily in the past are likely to become challenging.

Over the past several decades, researchers have identified hundreds of genes that contribute to inherited eye diseases, including Stargardt disease. Many studies continue to explore the biology and genetics of Stargardt disease, and of macular degeneration more generally.

The main goals are to better understand the natural course of the disease, to make contact with people who may be interested in future clinical trials, and to collect blood, skin, and DNA samples from those people.

Such mechanistic studies can lead to new treatment strategies. One strategy currently under study is to reduce the build-up of lipofuscin and other toxic byproducts in the retina.

In mice and larger animal models, an oral form of ALK slows the formation of lipofuscin deposits.

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